Plenary Lecture “Multiscale 4D genome organization in differentiation and development“
Giacomo Cavalli started in 1991 his Ph.D. at the Swiss Federal Institute of Technology and joined as a postdoc the University of Heidelberg in 1995. Since 1999, Giacomo is a group leader at the Institute of human Genetics (IGH) in Montpellier. He discovered transgenerational inheritance of chromatin states in Drosophila, together with Renato Paro. His lab showed that the 3D structure of chromosomes can be heritable and contributes to genome regulation. By high-resolution Hi-C technology, they discovered topologically associating domains (TADs) and described the anatomy of 3D architecture and dynamics in flies and mouse. They have also shown that PcG proteins regulate cell proliferation and have tumor suppression activity in flies. His current research aims to better understand the molecular mechanisms by which PcG and trxG proteins regulate their target genes, convey inheritance of chromatin states and orchestrate development.