Structure of Sessions

CHROMOSOME STRUCTURE AND NUCLEAR ARCHITECTURE

Session Chairs:

Dean Jackson, University of Manchester

Boris Vyskot, Institute of Biophysics CAS

Genetics deals with naive DNA while epigenetics is more realistic, it works with different chromatin structures and modified nucleosome units. Linear chromosomes of eukaryotes possess various domains which regulate the function of linked genes. The most sensitive regions of chromosomes are telomeres and centromeres which are responsible for chromosome integrity. There are also non-standard chromosomes, like sex chromosomes and B-chromosomes, playing the roles in sex determination and other developmental processes. Chromosomes are often specifically located within the nucleus, which may be critical for function of corresponding genes.

Topics:

Nucleus Telomeres Centromeres Heterochromatin Euchromatin

Modification of DNA and histones 3D nuclear structure Gene regulation

Position effect Sex chromosomes B-chromosomes

Tentative Titles of Lectures:

Dean Jackson “Using single cell analysis to link nuclear function and structure”

Andreas Houben “Drive and drift of supernumerary B chromosomes”

 

Specialized chromosomes

Session Chairs:

Tariq Ezaz, University of Canberra
Rachel O´Neil, University of Connecticut

 

Topics:

 Research applying genomics Cytogenetics and cell biology to understanding the function and evolution of sex chromosomes B chromosomes, and specialized chromosome structures such as the NOR Centromere and telomere.

Tentative Titles of Lectures:

Rachel O’Neil “Retroelements and the evolution of stable centromeres”

Tariq Ezaz “Chromosomics and the Evolution of Reptile Sex Chromosomes”

Cesar Martins “Fishing for B chromosome effects“

  

Population and evolutionary chromosome biology

Session Chairs:

Darren K. Griffin, University of Kent
Cesar Martins, Sao Paulo State University

The session covers all aspects of chromosome, chromatin and genomes in the evolutionary context of populations, species and taxa.

Topics:

  Chromosome/genome duplication Chromosomal diversification Chromosome painting Chromosome mapping Chromosome structure Genomic annotation  Karyology studies Phylogeny Polyploidy

Tentative Titles of Lectures:

Darren K. Griffin “Overview of the animal side of evolutionary biology”

Pat Heslop-Harrison “Overview of the plant side of evolutionary biology”

 

Mitosis and meiosis

Session Chairs:

Martin Anger, Masaryk University
Helen Tempest, Herbert Wertheim College of Medicine

 

Topics:

Control mechanisms of chromosome segregation in mitosis and meiosis (kinases, phosphatases, checkpoints) The role of condensin and cohesin in chromosome architecture Chromosomes in meiosis, chromosome pairing, synapsing, recombination The role chromosome architecture plays in chromosome segregation  Chromosome abnormalities, instability, segregation errors and aneuploidy Evidence of biased (non-Mendelian) meiotic chromosome segregation

Tentative Titles of Lectures:

Martin Anger "Challenges of chromosome segregation during transition from meiosis into mitosis”

Helen Tempest “Meiotic Nondisjunction: Insights into the Origin and Significance of Aneuploidy in Human Spermatozoa”

  

Chromatin and chromosome dynamics
EuroCellNet COST (CA15214) Session

Session Chairs:

Pavel Hozák. Institute of Molecular Genetics CAS
Masahiko Harata, Tohoku University

Chromatin is the fundamental structure of chromosomes, and its modulation is highly relevant to chromosome dynamics both in mitotic and interphase cells. This session will focus on chromatin organization and modulation and on their contribution to chromosome dynamics and functions. We will also discuss the involvement of chromatin and chromosome behaviours in various biological phenomena.

Topics:

Genome and epigenome Chromatin modifications and remodelling Chromosomal instability and genome integrity Nuclear proteins and RNAs Mitosis and meiosis  Chromosomal domains and nuclear subdomains Chromatin and chromosomes in development, aging, and diseases Imaging and analytical technologies Molecular simulations of chromatin

Tentative Titles of Lectures:

Masahiko Harata “Roles of histone- and actin-families in chromatin function and chromosome dynamics”

 

Genomics and genome organisation

Session Chairs:

Kerstin Bystricky, CBI Toulouse
Giacomo Cavalli, Institute of Human Genetics, CNRS, Montpellier, France

Recent advances in the analysis of 3D genome organization, dynamics and function, including the development of a panoply of genome-wide "chromosome conformation capture” approaches, have provided insights into high-resolution chromosome architecture, its links to transcriptional regulation, epigenomic marking of histones and DNA and other aspects of genome function, such as DNA replication, repair and DNA damage, as well as opening the way to the study of the role of genome architecture in evolution. I this session, we invite contributions discussing large-scale genome contact pattern changes in response to physiological or pathological events, as well as new approaches and the interplay of experimental, computational and modeling approaches in the study of genome structure and function.

Topics:

Chromosome folding and epigenome regulation 3D genome, transcription, DNA replication, repair and recombination Genome dynamics during differentiation, development, aging and in disease 3D genome folding, rearrangements and evolution Computational and modeling approaches for the study of 3D and 4D genome folding

Tentative Titles of Lectures:

Jop Kind “Untangling spatial genome organization: detailed insights from single-cell DamID”

 

Applied chromosome biology in agriculture

Session Chairs:

Jiří Rubeš, Veterinary Research Institute
Jaroslav Doležel, Institute of Experimental Botany

Cytogenetics profits from incorporating methods of molecular biology and genomics to provide insights into the organization and function of genetic information in economically important plants and animals. The acquired knowledge facilitates characterization of genome architecture as well as chromosome manipulation and contributes to creating varieties of agricultural crops and farm animal breeds with improved yield, quality and resistance to diseases and pests. The advanced methods of cytogenetics thus contribute to the efforts aiming at increasing the efficiency and quality of food production for the growing human population.

Topics:

Cytogenetics of agricultural crops and farm animals

Tentative Titles of Lectures:

Adam Lukaszewski “Practical applications of cytogenetics in germplasm enhancement in wheat”

 

New technologies in genome and cytogenetics research
59th Symposium of the Society for Histochemistry

Session Chairs:

Klara Weipoltshammer, Medical University of Vienna
Marco Biggiogera, University of Pavia

The investigation of chromatin-based procedures very often ends up with the need to study these processes at the single cell level. These approaches not only pose technical challenges such as specimen size or DNA-amount obtained, but also demand a thorough knowledge of biological factors when interpreting the results.

Therefore, we decided to lay the focus of the session „New technologies in genome and cytogenetics research” on innovative technologies designed to explore the structural and functional aspects of genome and chromatin at the single cell level. It is our aim to pool knowledge and stimulate discussion on how far we have succeeded in developing methodologies appropriate to clarify chromatin based cellular procedures.

Topics:

High-resolution chromosome conformation capture and the analysis of individual cells Genome editing technologies Omics techniques at the single cell level New developments of microscope based techniques to visualize chromatin and chromosomes Interpretation and Integration of large datasets in order to characterize processes in single cells

Tentative Titles of Lectures:

Luc Snyers “Examining the role of nuclear lamina proteins in post-mitotic nuclear envelope formation using CRISPR/Cas9 and time-lapse video microscopy”

Irene Masiello "High resolution dissection of interphase chromatin. Is 5mC the main character in chromatin condensation?"

 

 

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