Programme & Structure of Sessions



Keynote Lecture - Thomas Cremer

"Chromosomes in space and time - from past to future challenges"

Supported by COST EuroCellNet Action (CA15214)


COST EuroCellNet (CA15214) Session

Session Chairs:

Dean Jackson, University of Manchester

Boris Vyskot, Institute of Biophysics CAS

Genetics deals with naive DNA while epigenetics is more realistic, it works with different chromatin structures and modified nucleosome units. Linear chromosomes of eukaryotes possess various domains which regulate the function of linked genes. The most sensitive regions of chromosomes are telomeres and centromeres which are responsible for chromosome integrity. There are also non-standard chromosomes, like sex chromosomes and B-chromosomes, playing the roles in sex determination and other developmental processes. Chromosomes are often specifically located within the nucleus, which may be critical for function of corresponding genes.


Nucleus Telomeres Centromeres Heterochromatin Euchromatin

Modification of DNA and histones 3D nuclear structure Gene regulation

Position effect Sex chromosomes B-chromosomes

Invited Speakers:

Dean Jackson “Nuclear and chromosome context together define the gene-specific architecture that differentially controls heterogeneity of the immune response”

Andreas Houben “Drive and drift of supernumerary B chromosomes”


Specialized chromosomes

Session Chairs:

Tariq Ezaz, University of Canberra
Rachel O´Neil, University of Connecticut



 Research applying genomics Cytogenetics and cell biology to understanding the function and evolution of sex chromosomes B chromosomes, and specialized chromosome structures such as the NOR Centromere and telomere.

Invited Speakers:

Tariq Ezaz “Chromosomics and the Evolution of Reptile Sex Chromosomes”

Rachel O’Neil “Retroelements and the evolution of stable centromeres”

Cesar Martins “Fishing for B chromosome effects“


Population and evolutionary chromosome biology

Session Chairs:

Darren K. Griffin, University of Kent
Cesar Martins, Sao Paulo State University

The session covers all aspects of chromosome, chromatin and genomes in the evolutionary context of populations, species and taxa.


  Chromosome/genome duplication Chromosomal diversification Chromosome painting Chromosome mapping Chromosome structure Genomic annotation  Karyology studies Phylogeny Polyploidy

Invited Speakers:

Darren K. Griffin “Animal chromosome evolution: Karyome to genome to phenome”

Pat Heslop-Harrison “Chromosomal evolution and hybrids in crop plants”


Mitosis and meiosis
COST EuroCellNet (CA15214) Session

Session Chairs:

Martin Anger, Masaryk University
Helen Tempest, Herbert Wertheim College of Medicine



Control mechanisms of chromosome segregation in mitosis and meiosis (kinases, phosphatases, checkpoints) The role of condensin and cohesin in chromosome architecture Chromosomes in meiosis, chromosome pairing, synapsing, recombination The role chromosome architecture plays in chromosome segregation  Chromosome abnormalities, instability, segregation errors and aneuploidy Evidence of biased (non-Mendelian) meiotic chromosome segregation

Invited Speakers:

Martin Anger "Challenges of chromosome segregation during transition from meiosis into mitosis”

Helen Tempest “Meiotic Nondisjunction: Insights into the Origin and Significance of Aneuploidy in Human Spermatozoa”


Chromatin and chromosome dynamics
COST EuroCellNet (CA15214) Session

Session Chairs:

Pavel Hozák. Institute of Molecular Genetics CAS
Masahiko Harata, Tohoku University

Chromatin is the fundamental structure of chromosomes, and its modulation is highly relevant to chromosome dynamics both in mitotic and interphase cells. This session will focus on chromatin organization and modulation and on their contribution to chromosome dynamics and functions. We will also discuss the involvement of chromatin and chromosome behaviours in various biological phenomena.


Genome and epigenome Chromatin modifications and remodelling Chromosomal instability and genome integrity Nuclear proteins and RNAs Mitosis and meiosis  Chromosomal domains and nuclear subdomains Chromatin and chromosomes in development, aging, and diseases Imaging and analytical technologies Molecular simulations of chromatin

Invited Speakers:

Masahiko Harata “Cross-talk of histone and actin families affect chromosome dynamics in mitotic and interphase cells”

Maria Kristina Vartiainen "Nuclear actin in gene expression and genome organization"

Chris Toseland "Using the force to regulate gene expression: Myosin motors stabilise transcription factories"


Genomics and genome organisation
COST EuroCellNet (CA15214) Session

Session Chairs:

Kerstin Bystricky, CBI Toulouse
Giacomo Cavalli, Institute of Human Genetics, CNRS, Montpellier, France

Recent advances in the analysis of 3D genome organization, dynamics and function, including the development of a panoply of genome-wide "chromosome conformation capture” approaches, have provided insights into high-resolution chromosome architecture, its links to transcriptional regulation, epigenomic marking of histones and DNA and other aspects of genome function, such as DNA replication, repair and DNA damage, as well as opening the way to the study of the role of genome architecture in evolution. I this session, we invite contributions discussing large-scale genome contact pattern changes in response to physiological or pathological events, as well as new approaches and the interplay of experimental, computational and modeling approaches in the study of genome structure and function.


Chromosome folding and epigenome regulation 3D genome, transcription, DNA replication, repair and recombination Genome dynamics during differentiation, development, aging and in disease 3D genome folding, rearrangements and evolution Computational and modeling approaches for the study of 3D and 4D genome folding

Invited Speakers:

Jop Kind “Untangling spatial genome organization: detailed insights from single-cell DamID”

Eva Bártová "Dynamics of the 53BP1 protein accumulated info DNA repair foci or locally micro-irradiated chromatin"


Applied chromosome biology in agriculture

Session Chairs:

Jiří Rubeš, Veterinary Research Institute
Jaroslav Doležel, Institute of Experimental Botany

Cytogenetics profits from incorporating methods of molecular biology and genomics to provide insights into the organization and function of genetic information in economically important plants and animals. The acquired knowledge facilitates characterization of genome architecture as well as chromosome manipulation and contributes to creating varieties of agricultural crops and farm animal breeds with improved yield, quality and resistance to diseases and pests. The advanced methods of cytogenetics thus contribute to the efforts aiming at increasing the efficiency and quality of food production for the growing human population.


Cytogenetics of agricultural crops and farm animals

Invited Speakers:

Adam Lukaszewski “Practical applications of cytogenetics in germplasm enhancement in wheat”

Brendan Donaldson "Chromosomal landmarks of porcine reciprocal translocations"


New technologies in genome and cytogenetics research
59th Symposium of the Society for Histochemistry

Session Chairs:

Klara Weipoltshammer, Medical University of Vienna
Marco Biggiogera, University of Pavia

The investigation of chromatin-based procedures very often ends up with the need to study these processes at the single cell level. These approaches not only pose technical challenges such as specimen size or DNA-amount obtained, but also demand a thorough knowledge of biological factors when interpreting the results.

Therefore, we decided to lay the focus of the session „New technologies in genome and cytogenetics research” on innovative technologies designed to explore the structural and functional aspects of genome and chromatin at the single cell level. It is our aim to pool knowledge and stimulate discussion on how far we have succeeded in developing methodologies appropriate to clarify chromatin based cellular procedures.


High-resolution chromosome conformation capture and the analysis of individual cells Genome editing technologies Omics techniques at the single cell level New developments of microscope based techniques to visualize chromatin and chromosomes Interpretation and Integration of large datasets in order to characterize processes in single cells

Invited Speakers:

Luc Snyers “Examining the role of nuclear lamina proteins in post-mitotic nuclear envelope formation using CRISPR/Cas9 and time-lapse video microscopy”

Irene Masiello "High resolution dissection of interphase chromatin. Is 5mC the main character in chromatin condensation?"




Instuctions for SPEAKERS

Register now for the Pre-conference Workshop - COST EuroCellNet WG3 meeting - Focus on advanced microscopy-based techniques.

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